منابع مشابه
Suppression and enhancement of transcriptional noise by DNA looping.
DNA looping has been observed to enhance and suppress transcriptional noise but it is uncertain which of these two opposite effects is to be expected for given conditions. Here, we derive analytical expressions for the main quantifiers of transcriptional noise in terms of the molecular parameters and elucidate the role of DNA looping. Our results rationalize paradoxical experimental observation...
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By and large, gene expression levels in diploid organisms reflect the combined transcription of both copies, or alleles, of that gene. Notable exceptions include genes on the X chromosome and imprinted genes. The presence of genes in only one copy or in more than two copies can have major effects on the development and fitness of an organism. Many examples of these gene dosage effects can be fo...
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ژورنال
عنوان ژورنال: Pigment Cell & Melanoma Research
سال: 2008
ISSN: 1755-1471,1755-148X
DOI: 10.1111/j.1755-148x.2008.00502.x